CFR can refer to:
- Code of Federal Regulations of the United States
- Council on Foreign Relations, U.S. foreign policy think tank
- Campaign finance reform in the United States
- Cost and Freight, word used in international commerce
- CFR Cluj, Romanian football club
- Case fatality rate, term for proportion of people dying of a disease
- The Community of the Franciscan Friars of the Renewal, a Catholic Religious Community
- Charter of Fundamental Rights of the European Union
- Căile Ferate Române, the Romanian state railway
- Canadian Finals Rodeo
- Certified first responder
- Commander of the Order of the Federal Republic, Nigerian National Honour
- Chemin de Fer de la Rhune also nicknamed Le Petit train de la Rhune, a metre gauge rack railway in the French Pyrenees
- Crest Factor Reduction, a digital signal processing technique.
- Center for Family Representation, New York City-based nonprofit legal services organization
- Center for Forest Research, Canadian research center
- Culdee Fell Railway, fictional railway in W.V. Awdry's Railway Series
Main Site Subjects