Main Achievements and Ongoing Projects
- Establishment of the world first and only monitoring center for experimental animals in 1970. Appointed as an International Council for Laboratory Animal Science (ICLAS) Monitoring Center in 1979.
- Development and establishment of Tg-PVR mouse, in which a human poliovirus receptor gene is introduced, used as a safety testing for oral polio vaccine.
- Establishment of Tg-rasH2 mouse, in which a human prototype c-Ha-ras oncogene is introduced, and evaluation of their practical usefulness. Achieved a high level of accuracy in carcinogenicity testing for drugs and reduced the testing period to six months from the conventional two years' system.
- Developing spinal cord injury model and Parkinson's disease model using the common marmoset (New World monkey).
- Establishment of a severe immunodeficient mouse, NOD/Shi-scid, IL-2Rγnull mouse (NOD/SCID/IL-2Rγnull mouse, NOG mouse) and development of its applications to various animal experiments and testing systems.
Read more about this topic: Central Institute For Experimental Animals
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