Casein Kinase 2

The Casein kinase 2 (EC is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.

casein kinase 2,
alpha 1 polypeptide
Symbol CSNK2A1
Entrez 1457
HUGO 2457
OMIM 115440
RefSeq NM_001895
UniProt P68400
Other data
EC number
Locus Chr. 20 p13
casein kinase 2,
alpha prime polypeptide
Symbol CSNK2A2
Entrez 1459
HUGO 2459
OMIM 115442
RefSeq NM_001896
UniProt P19784
Other data
EC number
Locus Chr. 16
casein kinase 2,
beta polypeptide
Symbol CSNK2B
Entrez 1460
HUGO 2460
OMIM 115441
RefSeq NM_001320
UniProt P67870
Other data
EC number
Locus Chr. 6 p21.3

Other articles related to "casein kinase 2":

Casein Kinase 2, Alpha 1 - Interactions
... Casein kinase 2, alpha 1 has been shown to interact with CHEK1, FGF1, CDC25B, CREB-binding protein, Activating transcription factor 2, C-Fos, MAPK14, RELA, PIN1, PLEKHO1 ...