Calreticulin

Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene.

Calreticulin is a multifunctional protein that binds Ca2+ ions (a second messenger in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal (see inositol triphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum.

The term "Mobilferrin" is considered to be the same as calreticulin by some sources.

Read more about CalreticulinFunction, Clinical Significance, Role in Cancer, Interactions

Other articles related to "calreticulin":

Calreticulin - Interactions
... Calreticulin has been shown to interact with Perforin and NK2 homeobox 1. ...
CALR - Function - Transcription Regulation
... Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation ... Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors ... The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific ...
CALR - Clinical Significance
... Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients that contain anti-Ro/SSA antibodies ... is associated with increased autoantibody titers against calreticulin, but calreticulin is not a Ro/SS-A antigen ... Earlier papers referred to calreticulin as an Ro/SS-A antigen, but this was later disproven ...