Orthologs
The human gene, c14orf159 mRNA, is highly conserved in mammals and birds. Orthologs gathered from BLAST and BLAT searches reveal that the human c14orf159 mRNA sequence is conserved with a sequence identity of 98% in chimpanzees, 88% in mice, and 81% in platypus and chicken. The following table contains a list orthologs that were gathered from BLAST searches. Sequence alignments were performed using blastn to derive sequence identity, score, and E-values between the human c14orf159 variant 1 mRNA and its orthologs.
Human C14orf159 Orthologs-mRNA
| Genus and Species | Common Name | NCBI Accession number | Sequence Length (bp) | Sequence Identity | Score | E-Value |
|---|---|---|---|---|---|---|
| Homo sapiens | Human | NM_001102366 | 3164 | 100% | 0 | |
| Pan troglodytes | Chimpanzee | XM_510121 | 2974 | 98% | 4281 | 0 |
| Mus musculus | Mouse | NM_145448 | 3231 | 88% | 495 | 0 |
| Ornithorhynchus anatinus | Platypus | XM_00154336.1 | 1962 | 81% | 217 | 0 |
| Gallus gallus | Chicken | XM_421319 | 3389 | 81 | 50 | 0 |
The protein that the human gene c14orf159 encodes has been found to be highly conserved among mammals, birds, amphibians, fish, tunicates, cnidarians, and echinoderms. However, no protein orthologs have been found in nematodes, arthropods, fungi, protists, plants, bacteria, or archea. Fungi and bacteria contain the DUF1445 conserved domain which is found in human c14orf159 and its orthologs. BLAST and BLAT searches have been utilized to find orthologs to the c14orf159 protein. The following table lists protein orthologs for the human protein with sequence identity, sequence similarity, scores, and E-values derived from blastp sequence comparisons.
| Genus and Species | Common Name | NCBI Accession number | Sequence Length-Amino Acids | Sequence Identity | Sequence Similarity | Score | E-Value |
|---|---|---|---|---|---|---|---|
| Homo sapiens | Human | NP_001095839.1 | 564 | 100% | 100% | 0 | |
| Pan troglodytes | Chimpanzee | XP_510121.2 | 724 | 557/621 (89%) | 561/621 (90%) | 1109 | 0 |
| Ailuropoda melanoleuca | Panda | EFB15996.1 | 585 | 413/585 (70%) | 461/585 (78%) | 824 | 0 |
| Rattus norvegicus | Rat | XP_343096.2 | 618 | 423/618 (68%) | 470/618 (76%) | 774 | 0 |
| Mus musculus | Mouse | NP_663423.2 | 617 | 414/623 (66%) | 468/621 (75%) | 796 | 0 |
| Equus caballus | Horse | XP_001916913.1 | 581 | 390/585 (66%) | 433/585 (74%) | 728 | 6E-115 |
| Ornithorhynchus anatinus | Platypus | XP_001514386.1 | 653 | 358/628 (57%) | 443/628 (70%) | 696 | 0 |
| Gallus gallus | Chicken | XP_421319.2 | 617 | 330/614 (53%) | 414/614 (67%) | 630 | 0 |
| Xenopus tropicalis | Western clawed frog | CAJ82045.1 | 616 | 302/611 (49%) | 399/611 (65%) | 582 | 1E-170 |
| Danio rerio | Zebrafish | AAI244131.1 | 621 | 284/607 (46%) | 386/607 (63%) | 530 | 6E-155 |
| Branchiostoma floridae | Lancelet | XP_002612376.1 | 615 | 237/611 (38%) | 334/611 (54%) | 397 | 6E-115 |
| Ciona intestinalis | Vase tunicate | XP_001173256 | 486 | 161/501 (32%) | 241/501 (48%) | 244 | 5E-69 |
| Strongylocentrotus purpuratus | California purple sea urchin | XP_782739.1 | 631 | 9/33 (27%) | 15/33 (45%) | 320 | 5E-87 |
| Nematostella vectensis | Starlet sea anemone | XP_001637867 | 529 | 134/501 (26%) | 211/501 (42%) | 120 | 1E-31 |
Read more about this topic: C14orf159
Other articles related to "orthologs, ortholog":
... RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 12368 ... Ensembl ENSG00000138794 ENSMUSG00000027997 UniProt P55212 O08738 RefSeq (mR ... CASP6 orthologs have been identified in numerous mammals for which complete genome data are available ... Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts ...
... However, it does have orthologs stretching all the way back to yeast ... The following table represents a small selection of orthologs found using searches in BLAST and BLAT ... the vast diversity of species where FAM40A orthologs are found ...
... LepA orthologs have been found in bacteria and almost all eukaryotes ... acid identity of LepA among bacterial orthologs ranges from 55%-68% ... sequences, while the second form branches with cyanobacterial orthologs ...
... Orthologs, or orthologous genes, are genes in different species that originated by vertical descent from a single gene of the last common ancestor ... The term "ortholog" was coined in 1970 by Walter Fitch ... Orthologs often, but not always, have the same function ...
... Multiple sequence alignments were done with orthologs of the CYYR1 gene and they show that the protein sequence is highly conserved throughout all vertebrates ...