|Molecular function||• guanyl-nucleotide exchange factor activity
• Rho guanyl-nucleotide exchange factor activity
• protein binding
• phospholipid binding
• protein domain specific binding
• Rac guanyl-nucleotide exchange factor activity
|Cellular component||• cytosol
• ruffle membrane
|Biological process||• apoptotic process
• small GTPase mediated signal transduction
• lamellipodium assembly
• regulation of Rho protein signal transduction
• intracellular signal transduction
• filopodium assembly
• nerve growth factor receptor signaling pathway
• regulation of small GTPase mediated signal transduction
|Sources: Amigo / QuickGO|
131.59 – 131.8 Mb
34.68 – 34.81 Mb
Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.
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