Identifiers Symbols ARHGEF4; ASEF; ASEF1; GEF4; STM6 External IDs OMIM: 605216 MGI: 2442507 HomoloGene: 49414 GeneCards: ARHGEF4 Gene

Gene Ontology
Molecular function guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
protein binding
phospholipid binding
protein domain specific binding
Rac guanyl-nucleotide exchange factor activity
Cellular component cytosol
ruffle membrane
Biological process apoptotic process
small GTPase mediated signal transduction
lamellipodium assembly
regulation of Rho protein signal transduction
intracellular signal transduction
filopodium assembly
nerve growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 50649 226970 Ensembl ENSG00000136002 ENSMUSG00000037509 UniProt Q9NR80 Q7TNR9 RefSeq (mRNA) NM_015320 NM_183019 RefSeq (protein) NP_056135 NP_898840 Location (UCSC) Chr 2:
131.59 – 131.8 Mb Chr 1:
34.68 – 34.81 Mb PubMed search

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.

Read more about ARHGEF4:  Model Organisms, Interactions

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ARHGEF4 - Interactions
... ARHGEF4 has been shown to interact with APC. ...