Apo or APO may refer to:
- African Press Organization
- Acting Pilot Officer, the lowest commissioned grade in the Royal Air Force
- Acute Pulmomary Oedema, fluid accumulation on the lungs
- African Political Organization, a Coloured political organization in early twentieth century South Africa
- Alpha Phi Omega, a U.S. service fraternity
- Alpha Psi Omega, a U.S. honors theatre society
- Apo, a god of mountains in Inca mythology
- Serok Apo or Abdullah Öcalan, Kurdistan Workers Party leader
- Apochromat, a type of photographic or other lens
- Apoprotein, a protein without its bound cofactor
- Apotex, Canadian pharmaceutical company, producer of generic drugs
- Application Performance Optimization
- Army Post Office: chiefly U.S. Army and U.S. Air Force postal services. Also See military mail
- Association for Professional Observers, an association of fisheries observers
- Außerparlamentarische Opposition, a political protest movement in West Germany during the 1960s and 1970s
- Authorized Personnel Only, a fictional black ops unit on Alias
- After Peak Oil, an epoch used in dating years following the estimated Peak of Global Oil Production
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