Amylin

Amylin

Identifiers Symbols IAPP; DAP; IAP External IDs OMIM: 147940 MGI: 96382 HomoloGene: 36024 GeneCards: IAPP Gene

Gene Ontology
Molecular function receptor binding
hormone activity
Cellular component extracellular region
extracellular space
neuronal cell body
Biological process apoptotic process
signal transduction
cell-cell signaling
sensory perception of pain
endocrine pancreas development
negative regulation of cell differentiation
negative regulation of bone resorption
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3375 15874 Ensembl ENSG00000121351 ENSMUSG00000041681 UniProt P10997 P12968 RefSeq (mRNA) NM_000415.2 NM_010491.2 RefSeq (protein) NP_000406.1 NP_034621.1 Location (UCSC) Chr 12:
21.51 – 21.53 Mb Chr 6:
142.3 – 142.3 Mb PubMed search

Amylin, or Islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.

IAPP is processed from an 89-residue coding sequence. Proislet Amyloid Polypeptide (proIAPP,Proamylin, Amyloid Polypeptide Precursor, Proislet Protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.

Read more about Amylin:  Structure and Synthesis, Regulation, Function, Structure, History and Nomenclature, Role in Disease, Clinical Significance, Pharmacology, Receptors

Other articles related to "amylin":

Pramlintide - Pharmacology
... Pramlintide is an analogue of amylin, a small peptide hormone that is released into the bloodstream by the β-cells of the pancreas along with insulin ... Like insulin, amylin is deficient in individuals with Type I diabetes ... By augmenting endogenous amylin, pramlintide aids in the absorption of glucose by slowing gastric emptying, promoting satiety via hypothalamic receptors (different receptors than for GLP-1 ...
Amylin Pharmaceuticals
... Amylin Pharmaceuticals is a biopharmaceutical company based in San Diego, CA, that was founded in 1987 ... Currently, Amylin produces three drugs, Symlin (pramlintide acetate) and Byetta (exenatide) and Bydureon (exenatide extended-release) ... Amylin also is working on producing analog of human leptin, metreleptin ...
Amylin - Receptors
... There appears to be at least three distinct receptor complexes that bind with high affinity to amylin ... All three complexes contain the calcitonin receptor at the core, plus one of three receptor activity-modifying proteins, RAMP1, RAMP2, or RAMP3 ...
Kelaroo - Expanded Collaboration With Amylin Pharmaceuticals
... On September 5, 2007, Kelaroo announced that it had expanded its contract research with Amylin Pharmaceuticals and received a strategic equity investment ... Kelaroo's proprietary SeqR(TM)technology was utilized to develop Amylin's PHINDER system for peptide hormone identification and optimization ...
Subsidiaries, Acquisitions and Strategic Global Alliances - Biocon and Amylin
... In 2009, Biocon and Amylin Pharmaceuticals of the United States entered into an agreement to develop, commercialize and manufacture a novel peptide therapeutic for the potential ... Amylin provides expertise in peptide hormone development, particularly in the area of phybrid technology and metabolic disease therapeutics ...