Amylin

Amylin

Identifiers Symbols IAPP; DAP; IAP External IDs OMIM: 147940 MGI: 96382 HomoloGene: 36024 GeneCards: IAPP Gene

Gene Ontology
Molecular function	• receptor binding • hormone activity
Cellular component	• extracellular region • extracellular space • neuronal cell body
Biological process	• apoptotic process • signal transduction • cell-cell signaling • sensory perception of pain • endocrine pancreas development • negative regulation of cell differentiation • negative regulation of bone resorption
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3375 15874 Ensembl ENSG00000121351 ENSMUSG00000041681 UniProt P10997 P12968 RefSeq (mRNA) NM_000415.2 NM_010491.2 RefSeq (protein) NP_000406.1 NP_034621.1 Location (UCSC) Chr 12:
21.51 – 21.53 Mb Chr 6:
142.3 – 142.3 Mb PubMed search

Amylin, or Islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.

IAPP is processed from an 89-residue coding sequence. Proislet Amyloid Polypeptide (proIAPP,Proamylin, Amyloid Polypeptide Precursor, Proislet Protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.