Allosteric Regulation

In biochemistry, allosteric regulation is the regulation of an enzyme or other protein by binding an effector molecule at the protein's allosteric site (that is, a site other than the protein's active site). Effectors that enhance the protein's activity are referred to as allosteric activators, whereas those that decrease the protein's activity are called allosteric inhibitors. The term allostery comes from the Greek allos (ἄλλος), "other", and stereos (στερεὀς), "solid (object)", in reference to the fact that the regulatory site of an allosteric protein is physically distinct from its active site. Allosteric regulations are a natural example of control loops, such as feedback from downstream products or feedforward from upstream substrates. Long-range allostery is especially important in cell signaling.

Read more about Allosteric RegulationModels of Allosteric Regulation, Non-regulatory Allostery, Pharmacology

Other articles related to "allosteric regulation, allosteric, regulation":

Allosteric Regulation - Pharmacology - Allosteric Sites As Drug Targets
... Allosteric sites may represent a novel drug target ... There are a number of advantages in using allosteric modulators as preferred therapeutic agents over classic orthosteric ligands ... For example, G protein-coupled receptor (GPCR) allosteric binding sites have not faced the same evolutionary pressure as orthosteric sites to accommodate an endogenous ligand, so are more diverse ...
Morpheein - Implications For Allosteric Regulation
... The morpheein model of allosteric regulation has similarities to and differences from other models ... model (the Monod, Wyman and Changeux (MWC) model) of allosteric regulation requires all subunits to be in the same conformation or state within an oligomer like the ...
Malate Dehydrogenase - Allosteric Regulation
... Because malate dehydrogenase is closely tied to the citric acid cycle, regulation is highly dependent on TCA products ... It is believed that there is an allosteric regulatory site on the enzyme where citrate can bind to and drive the reaction equilibrium in either direction ...

Famous quotes containing the word regulation:

    Lots of white people think black people are stupid. They are stupid themselves for thinking so, but regulation will not make them smarter.
    Stephen Carter (b. 1954)