Phenotype | Description | Onset | Approximate Relative Frequency |
---|---|---|---|
Asymptomatic | No neurologic or adrenal involvement | Most women under 30 do not have any neurologic involvement | Diminishes with age |
Mild myelopathy | Increased deep tendon reflexes, sensory changes in lower extremities | Adulthood | Approximately 50% of women over 40 years of age |
Moderate to severe myeloneuropathy | Similar to male AMN phenotype, but later onset and milder presentation | Adulthood | Approximately 15% of women over 40 years of age |
Cerebral involvement | Progressive dementia and decline | Rare in childhood, more common in adults | ~2% |
Adrenal involvement | Primary adrenal insufficiency | Any age | ~1% |
Read more about this topic: Adrenomyeloneuropathy, Clinical Presentation
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