ACE Inhibitors Drug Design
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain specific ACE inhibitors began.
Read more about ACE Inhibitors Drug Design: Development of First Generation ACE Inhibitors, Discovery of 2 Active Sites: C-domain and N-domain, Drug Design of Keto-ACE and Its Ketomethylene Derivatives, Drug Design of Silanediol, Phosphinic Peptides
Other articles related to "ace inhibitors drug design, inhibitor, ace":
... RXPA380 was the first inhibitor that was highly selective of the C-domain of ACE, it has the formula Phe-Phe-Pro-Trp ... accommodate in the active site of germinal ACE ... Modeling of RXPA380-ACE complex showed that the pseudo-proline residue of the inhibitor was surrounded by amino acids similar to that of the N-domain thus interactions with S2 ...
Famous quotes containing the words design, drug and/or ace:
“With wonderful art he grinds into paint for his picture all his moods and experiences, so that all his forces may be brought to the encounter. Apparently writing without a particular design or responsibility, setting down his soliloquies from time to time, taking advantage of all his humors, when at length the hour comes to declare himself, he puts down in plain English, without quotation marks, what he, Thomas Carlyle, is ready to defend in the face of the world.”
—Henry David Thoreau (18171862)
“If an addict who has been completely cured starts smoking again he no longer experiences the discomfort of his first addiction. There exists, therefore, outside alkaloids and habit, a sense for opium, an intangible habit which lives on, despite the recasting of the organism.... The dead drug leaves a ghost behind. At certain hours it haunts the house.”
—Jean Cocteau (18891963)
“I do not object to Gladstones always having the ace of trumps up his sleeve, but only to his pretence that God had put it there.”
—Henry Labouchere (18311912)