ACE Inhibitors Drug Design
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain specific ACE inhibitors began.
Read more about ACE Inhibitors Drug Design: Development of First Generation ACE Inhibitors, Discovery of 2 Active Sites: C-domain and N-domain, Drug Design of Keto-ACE and Its Ketomethylene Derivatives, Drug Design of Silanediol, Phosphinic Peptides
Other articles related to "ace inhibitors drug design, inhibitor, ace":
... RXPA380 was the first inhibitor that was highly selective of the C-domain of ACE, it has the formula Phe-Phe-Pro-Trp ... accommodate in the active site of germinal ACE ... Modeling of RXPA380-ACE complex showed that the pseudo-proline residue of the inhibitor was surrounded by amino acids similar to that of the N-domain thus interactions with S2 ...
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