TGF Beta Receptor 2

TGF Beta Receptor 2

Identifiers Symbols TGFBR2; AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII External IDs OMIM: 190182 MGI: 98729 HomoloGene: 2435 ChEMBL: 4267 GeneCards: TGFBR2 Gene EC number 2.7.11.30

Gene Ontology
Molecular function transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
glycosaminoglycan binding
mitogen-activated protein kinase kinase kinase binding
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
SMAD binding
metal ion binding
transforming growth factor beta binding
Cellular component cytosol
plasma membrane
caveola
external side of plasma membrane
integral to membrane
receptor complex
transforming growth factor beta receptor homodimeric complex
Biological process blood vessel development
patterning of blood vessels
vasculogenesis
in utero embryonic development
positive regulation of mesenchymal cell proliferation
lens development in camera-type eye
positive regulation of tolerance induction to self antigen
positive regulation of B cell tolerance induction
positive regulation of T cell tolerance induction
protein phosphorylation
receptor-mediated endocytosis
apoptotic process
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
smoothened signaling pathway
gastrulation
brain development
heart development
embryo implantation
aging
response to nutrient
positive regulation of cell proliferation
response to mechanical stimulus
response to glucose stimulus
positive regulation of epithelial cell migration
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
negative regulation of transforming growth factor beta receptor signaling pathway
organ regeneration
activation of protein kinase activity
embryonic hemopoiesis
wound healing
regulation of cell proliferation
response to drug
myeloid dendritic cell differentiation
positive regulation of skeletal muscle tissue regeneration
response to estrogen stimulus
digestive tract development
positive regulation of smooth muscle cell proliferation
embryonic cranial skeleton morphogenesis
positive regulation of NK T cell differentiation
cartilage development
palate development
negative regulation of cardiac muscle cell proliferation
pathway-restricted SMAD protein phosphorylation
bronchus morphogenesis
trachea formation
mammary gland morphogenesis
lung lobe morphogenesis
response to cholesterol
positive regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7048 21813 Ensembl ENSG00000163513 ENSMUSG00000032440 UniProt P37173 Q62312 RefSeq (mRNA) NM_001024847 NM_009371 RefSeq (protein) NP_001020018 NP_033397 Location (UCSC) Chr 3:
30.65 – 30.74 Mb Chr 9:
116.09 – 116.18 Mb PubMed search

Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.

It is a tumor suppressor gene.

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Read more about TGF Beta Receptor 2:  Interactions, Domain Architecture, See Also, External Links

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