Synthase

In biochemistry, a synthase is an enzyme that catalyses a synthesis process. Following the EC number classification, they belong to the group of lyases, with ligases catalysing the reverse reaction.

Note that, originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas synthetases do use nucleoside triphosphates. However, the Joint Commission on Biochemical Nomenclature (JCBN) dictates that 'synthase' can be used with any enzyme that catalyzes synthesis (whether or not it uses nucleoside triphosphates), whereas 'synthetase' is to be used synonymously with 'ligase'.

Read more about Synthase:  Examples

Other articles related to "synthase":

Shikimate Kinase - Background
... The shikimate pathway consists of seven enzymatic reactions by which phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the common precursor of the aromatic amino acids phenylalanine, tyrosine, and tryptophan ... The aromatic amino acids are used in the synthesis of proteins and, in plants, fungi, and bacteria, give rise to a number of other specialized metabolites, such as phenylpropanoids and alkaloids ...
Lactose Synthase
... Lactose synthase is an enzyme that generates lactose from glucose and UDP-galactose ... It consists of N-acetyllactosamine synthase and alpha-lactalbumin ... is expressed in response to prolactin, increases the affinity of N-acetyllactosamine synthase for its substrate, causing increased production of lactose during lactation ...
Leukotriene-C4 Synthase
... In enzymology, a leukotriene-C4 synthase (EC 4.4.1.20) is an enzyme that catalyzes the chemical reaction leukotriene C4 leukotriene A4 + glutathione Hence, this enzyme has one substrate, leukotriene C4, and two ... Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14 ...
Synthase - Examples
... ATP synthase Citrate synthase Tryptophan synthase Pseudouridine synthase Fatty acid synthase Cellulose synthase (UDP-forming) Cellulose synthase (GDP-forming) ...
MAPEG Family
... Included are the 5-lipoxygenase-activating protein (gene FLAP), leukotriene C4 synthase (EC 2.5.1.37), which catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4 ... Another example is prostaglandin E synthase ... Because of structural similarities in the active sites of FLAP, LTC4 synthase, and PGE synthase, substrates for each enzyme can compete with one another and modulate ...