Sempill or Semple was a Scottish family including several notables:
- Robert Sempill (c.1530-1595), balladeer
- Robert Sempill the younger (1595?-1663?), writer, son of Robert
- Francis Sempill (1616?-1682), writer, son of Robert the younger
- Sir James Sempill (1566-1626), companion of Mary, queen of Scots
- William Forbes-Sempill, 19th Lord Sempill (1893-1965) Master of Sempill, British pioneering aviator and Japanese spy.
See also:
- Lord Sempill (title)
- Hugh Sempill (1596-1654), Scottish mathematician, after whom Simpelius crater is named
- Sempill Mission 1921 military mission to Japan