Mazatec shamans crush the leaves to extract leaf juices from about 20 to 80 (about 50g/2 oz to 200g/7 oz.) or more fresh leaves. They usually mix these juices with water to create an infusion or 'tea' which they drink to induce visions in ritual healing ceremonies.
Chewing and swallowing a large number of fresh leaves is the other Mazatec method. Oral consumption of the leaf makes the effects come on more slowly, over a period of 10 to 20 minutes. The experience, from the onset of effects, lasts from about 30 minutes up to one and a half hours.
Doses for chewing vastly exceed doses used for smoking. By calculating the concentrations per leaf ("an average concentration of 2.45 mg per gram" of leaf), the average weight per leaf ("about 50 g" per 20 leaves, or 2.5g/leaf), and the standard dose for chewing (about 8-28 leaves), the doses can range from about 50 mg to 172 mg.
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