Protein Tyrosine Phosphatase

Protein Tyrosine Phosphatase

Protein tyrosine phosphatases (EC 3.1.3.48, PTPs, phosphotyrosine phosphatase, phosphoprotein phosphatase (phosphotyrosine), phosphotyrosine histone phosphatase, protein phosphotyrosine phosphatase, tyrosylprotein phosphatase, phosphotyrosine protein phosphatase, phosphotyrosylprotein phosphatase, tyrosine O-phosphate phosphatase, PPT-phosphatase, PTPase, protein phosphatase, PTP-phosphatase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. As a consequence, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; EC 3.1.3.48) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation.

Read more about Protein Tyrosine Phosphatase:  Functions, Expression Pattern

Other articles related to "protein tyrosine phosphatase, protein, phosphatase, tyrosine":

PTPN2
3807 GeneCards PTPN2 Gene EC number 3.1.3.48 Gene Ontology Molecular function • protein tyrosine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family ... Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor ...
CDC14B
... CDC14B Gene EC number 3.1.3.48 3.1.3.16, 3.1.3.48 Gene Ontology Molecular function • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity ... The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family ... This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role ...
Tyrosine-t RNA Ligase
... In enzymology, a tyrosine-tRNA ligase (EC 6.1.1.1) is an enzyme that catalyzes the chemical reaction ATP + L-tyrosine + RNA AMP + diphosphate + L-tyrosyl-tRNATyr ... This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and aminoacyl-trna biosynthesis ...
Tyrosine - Medical Use
... Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine) but has little if any effect on mood ... A number of studies have found tyrosine to be useful during conditions of stress, cold, fatigue, loss of a loved one such as in death or divorce, prolonged work and sleep deprivation ... Tyrosine does not seem to have any significant effect on mood, cognitive or physical performance in normal circumstances ...

Famous quotes containing the word protein:

    Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.
    Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)