PIM1

PIM1

Identifiers Symbols PIM1; PIM External IDs OMIM: 164960 MGI: 97584 HomoloGene: 11214 ChEMBL: 2147 GeneCards: PIM1 Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• protein serine/threonine kinase activity • protein binding • ATP binding • transcription factor binding • manganese ion binding • ribosomal small subunit binding
Cellular component	• nucleus • cytoplasm • plasma membrane
Biological process	• protein phosphorylation • apoptotic process • cell cycle • multicellular organismal development • cell proliferation • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S • negative regulation of apoptotic process • negative regulation of sequence-specific DNA binding transcription factor activity • protein autophosphorylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5292 18712 Ensembl ENSG00000137193 ENSMUSG00000024014 UniProt P11309 P06803 RefSeq (mRNA) NM_001243186 NM_008842 RefSeq (protein) NP_001230115 NP_032868 Location (UCSC) Chr 6:
37.14 – 37.14 Mb Chr 17:
29.49 – 29.5 Mb PubMed search

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.

Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus. Subsequently, the oncogene has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies. Primarily expressed in spleen, thymus, bone marrow, prostate, oral epithelial, hippocampus and fetal liver cells, Pim-1 has also been found to be highly expressed in cell cultures isolated from human tumors. Pim-1 is mainly involved in cell cycle progression, apoptosis and transcriptional activation, as well as more general signal transduction pathways.