PIM1
Gene Ontology | |
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Molecular function | • protein serine/threonine kinase activity • protein binding • ATP binding • transcription factor binding • manganese ion binding • ribosomal small subunit binding |
Cellular component | • nucleus • cytoplasm • plasma membrane |
Biological process | • protein phosphorylation • apoptotic process • cell cycle • multicellular organismal development • cell proliferation • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S • negative regulation of apoptotic process • negative regulation of sequence-specific DNA binding transcription factor activity • protein autophosphorylation |
Sources: Amigo / QuickGO |
37.14 – 37.14 Mb
29.49 – 29.5 Mb
Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.
Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus. Subsequently, the oncogene has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies. Primarily expressed in spleen, thymus, bone marrow, prostate, oral epithelial, hippocampus and fetal liver cells, Pim-1 has also been found to be highly expressed in cell cultures isolated from human tumors. Pim-1 is mainly involved in cell cycle progression, apoptosis and transcriptional activation, as well as more general signal transduction pathways.
Read more about PIM1: Gene, Protein Structure, Activation and Stabilization, Interactions, Clinical Implications