Peripheral Membrane Protein

Peripheral Membrane Protein

Peripheral membrane proteins are proteins that adhere only temporarily to the biological membrane with which they are associated. These molecules attach to integral membrane proteins, or penetrate the peripheral regions of the lipid bilayer. The regulatory protein subunits of many ion channels and transmembrane receptors, for example, may be defined as peripheral membrane proteins. In contrast to integral membrane proteins, peripheral membrane proteins tend to collect in the water-soluble component, or fraction, of all the proteins extracted during a protein purification procedure. Proteins with GPI anchors are an exception to this rule and can have purification properties similar to those of integral membrane proteins.

The reversible attachment of proteins to biological membranes has shown to regulate cell signaling and many other important cellular events, through a variety of mechanisms. For example, the close association between many enzymes and biological membranes may bring them into close proximity with their lipid substrate(s). Membrane binding may also promote rearrangement, dissociation, or conformational changes within many protein structural domains, resulting in an activation of their biological activity. Additionally, the positioning of many proteins are localized to either the inner or outer surfaces or leaflets of their resident membrane. This facilitates the assembly of multi-protein complexes by increasing the probability of any appropriate protein–protein interactions.

Read more about Peripheral Membrane Protein:  Binding of Peripheral Proteins To The Lipid Bilayer, Membrane Binding Mechanisms, Spatial Position in Membrane

Other articles related to "membranes, membrane proteins, membrane, proteins, peripheral membrane protein, protein":

Membrane - Industrial Use
... Certain features of membranes are responsible for the interest in using them as substitutes to consolidated industrial separation processes, like distillation, adsorption or ... facilitates the incorporation of more efficient membranes ...
Epsin
... Epsins are the family of membrane proteins that are important in creating the needed membrane curvature ... Epsins contribute to various needed membrane deformations like endocytosis and block vesicle formation during mitosis ... Epsins have many different domains to interact with various proteins related to endocytosis ...
Bruch's Membrane - Pathology
... Bruch's membrane thickens with age, slowing the transport of metabolites ... and Basal Lamellar Deposits BLamD) on and within the membrane, primarily consisting of phospholipids ... This build up seems to fragment the membrane into a lamellar structure more like puff-pastry than a barrier ...
Peripheral Membrane Protein - Categories of Peripheral Proteins - Polypeptide Hormones, Toxins, and Antimicrobial Peptides
... toxins, inhibitors, or antimicrobial peptides interact specifically with transmembrane protein complexes ... They can also accumulate at the lipid bilayer surface, prior to binding their protein targets ... often positively charged and interact electrostatically with anionic membranes ...
Bruch's Membrane - Layers
... Bruch's membrane consists of five layers (from inside to outside) the basement membrane of the retinal pigment epithelium the inner collagenous zone a central band of elastic fibers the outer ...

Famous quotes containing the words protein and/or peripheral:

    Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.
    Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)

    If we are to change our world view, images have to change. The artist now has a very important job to do. He’s not a little peripheral figure entertaining rich people, he’s really needed.
    David Hockney (b. 1937)