PEI or Pei may refer to:
- Places
 
- Prince Edward Island, a province of Canada
 - Pei, Tibet, a town in Tibet
 - Pei County (沛县), a county in Xuzhou, Jiangsu, China
 
- People
 
- I. M. Pei (貝聿銘) (born 1917), a Chinese-American architect
 - Mario Pei (1901–1978), an Italian-American linguist and polyglot
 - Pei Wenzhong (裴文中) (1904–1982), a Chinese anthropologist
 - Yan Pei-Ming (born 1960), a Chinese born painter
 
- Polymers
 
- Polyethylenimine, a type of water-soluble polymer
 - Polyetherimide, an amorphous, amber-to-transparent thermoplastic with characteristics similar to the related plastic PEEK
 
- Other
 
- Pei (פ) a letter in the Hebrew alphabet
 - Shar Pei, a breed of dog whose distinctive feature is deep wrinkles
 - Pei (surname) (裴), a Chinese surname
 - PEI, Patient Episode Initiation, a chargeable service item under the Medicare (Australia) benefits scheme
 - Private Equity International, a financial magazine
 
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