Patent Ductus Arteriosus

Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate's ductus arteriosus fails to close after birth. Early symptoms are uncommon, but in the first year of life include increased work of breathing and poor weight gain. With age, the PDA may lead to congestive heart failure if left uncorrected. The ductus arteriosus is a normal fetal blood vessel that closes soon after birth. In a patent ductus arteriosus (PDA) the vessel does not close and remains "patent" resulting in irregular transmission of blood between two of the most important arteries close to the heart, the aorta and the pulmonary artery. PDA is common in neonates with persistent respiratory problems such as hypoxia, and has a high occurrence in premature children. In hypoxic newborns, too little oxygen reaches the lungs to produce sufficient levels of bradykinin and subsequent closing of the DA. Premature children are more likely to be hypoxic and thus have PDA because of their underdeveloped heart and lungs.

A patent ductus arteriosus allows a portion of the oxygenated blood from the left heart to flow back to the lungs by flowing from the aorta (which has higher pressure) to the pulmonary artery. If this shunt is substantial, the neonate becomes short of breath: the additional fluid returning to the lungs increases lung pressure to the point that the neonate has greater difficulty inflating the lungs. This uses more calories than normal and often interferes with feeding in infancy. This condition, as a constellation of findings, is called congestive heart failure.

In some cases, such as in transposition of the great vessels (the pulmonary artery and the aorta), a PDA may need to remain open. In this cardiovascular condition, the PDA is the only way that oxygenated blood can mix with deoxygenated blood. In these cases, prostaglandins are used to keep the patent ductus arteriosus open.

Read more about Patent Ductus Arteriosus:  Signs and Symptoms, Diagnosis, Treatment, Prevention, Etiology, Prognosis, History, Additional Images

Other articles related to "patent ductus arteriosus, ductus arteriosus, ductus":

Patent Ductus Arteriosus - Additional Images
... patent ductus arteriosus An echocardiogram of a stented persisting ductus arteriosus ... Pulmonary artery not seen An echocardiogram of a coiled persisting ductus arteriosus ...
Patent Ductus Arteriosus
... Failure of a child's DA to close after birth results in a condition called patent ductus arteriosus and the generation of a left-to-right shunt ... are responsible for maintaining the ductus arteriosus by dilation of the vascular smooth muscles ... A patent ductus arteriosus affects around 40% of infants with Down syndrome (DS) ...
Prostaglandin E1 - Medical Uses - Patent Ductus Arteriosus
... Alprostadil is also used in maintaining a patent ductus arteriosus in newborns ... This is primarily useful when there is threat of premature closure of the ductus arteriosus in an infant with ductal-dependent congenital heart disease, including cyanotic lesions (e.g ...
Ductus Arteriosus
... In the developing fetus, the ductus arteriosus (DA), also called the ductus Botalli, is a blood vessel connecting the pulmonary artery to the aortic arch ... There are two other fetal shunts, the ductus venosus and the foramen ovale ...

Famous quotes containing the word patent:

    There is a patent office at the seat of government of the universe, whose managers are as much interested in the dispersion of seeds as anybody at Washington can be, and their operations are infinitely more extensive and regular.
    Henry David Thoreau (1817–1862)