Organophosphate Poisoning

Organophosphate poisoning results from exposure to organophosphates (OPs), which cause the inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine (ACh) in the body. Organophosphate poisoning most commonly results from exposure to insecticides or nerve agents. OPs are one of the most common causes of poisoning worldwide, and are frequently intentionally used in suicides in agrarian areas. There are around 1 million OP poisonings per year with several hundred thousand resulting in fatalities annually.

Organophosphates inhibit AChE, causing OP poisoning by phosphorylating the serine hydroxyl residue on AChE, which inactivates AChE. AChE is critical for nerve function, so the irreversible blockage of this enzyme, which causes acetylcholine accumulation, results in muscle overstimulation. This causes disturbances across the cholinergic synapses and can only be reactivated very slowly, if at all. Paraoxonase (PON1) is a key enzyme involved in OP pesticides and has been found to be critical in determining an organism's sensitivity to OP exposure.

Read more about Organophosphate PoisoningSigns and Symptoms, Cause, Pathophysiology, Diagnosis, Treatment, Society and Culture, Research

Other articles related to "organophosphate poisoning, organophosphates, poisoning, organophosphate":

results">Organophosphate Poisoning - Research
... The use of the organophosphates in aviation lubricating oils and hydraulic fluids and its impact on health and flight safety is currently being researched ... Purdey (1998) suggested that organophosphates, in particular Phosmet, induced the transmissible spongiform encephalopathy epidemic of BSE ...
Organophosphate Poisoning
... Many organophosphates are potent nerve agents, functioning by inhibiting the action of acetylcholinesterase (AChE) in nerve cells ... They are one of the most common causes of poisoning worldwide, and are frequently intentionally used in suicides in agricultural areas ... Neurotransmitters such as acetylcholine (which is affected by organophosphate pesticides) are profoundly important in the brain's development, and ...
Chrysomya Megacephala - Larval-state Poisoning Detection
... In any part of the world that uses organophosphates, C ... Organophosphate compounds are used in agriculture and are highly toxic ... Organophosphate poisoning often engenders death, and in many cases, by evaluating the body tissue and fluids, the toxin can be identified as the source of the poisoning ...
Atropine - Physiological Effects and Uses - Treatment For Organophosphate Poisoning
... Atropine is not an actual antidote for organophosphate poisoning ... the action of acetylcholine at muscarinic receptors, atropine also serves as a treatment for poisoning by organophosphate insecticides and nerve gases, such as tabun (GA), sarin (GB ... diaphoresis, gastrointestinal motility, emesis) symptoms caused by organophosphate poisoning ...

Famous quotes containing the word poisoning:

    The most winning woman I ever knew was hanged for poisoning three little children for their insurance-money, and the most repellent man of my acquaintance is a philanthropist who has spent nearly a quarter of a million upon the London poor.
    Sir Arthur Conan Doyle (1859–1930)