Nuclear Receptor

Nuclear Receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism.

Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally only happens when a ligand — a molecule that affects the receptor's behavior — is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor, which, in turn, activates the receptor, resulting in up-regulation or down-regulation of gene expression.

A unique property of nuclear receptors that differentiates them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. As a consequence, nuclear receptors play key roles in both embryonic development and adult homeostasis. As discussed below, nuclear receptors may be classified according to either mechanism or homology.

Read more about Nuclear Receptor:  Species Distribution, Ligands, Structure, Mechanism of Action, Coregulatory Proteins, Agonism Vs Antagonism, Family Members, History, See Also

Other articles related to "nuclear receptor, receptor, nuclear receptors, nuclear":

Nuclear Receptor - See Also
... Receptor Intracellular receptor NucleaRDB Steroid hormone receptor Transcription factor Obesogen ...
Small Heterodimer Partner
... The small heterodimer partner (SHP) also known as NR0B2 (nuclear receptor subfamily 0, group B, member 2) is a protein that in humans is encoded by the NR0B2 gene ... SHP is a member of the nuclear receptor family of intracellular transcription factors ... SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain ...
Transcription Coregulators - Histone Acyltransferases - Nuclear Receptor Corepressors
... surface of the ligand binding domain of nuclear receptors, but through a LXXXIXXX(I/L) motif of amino acids (where L = leucine, I = isoleucine and X = any amino acid) ... to the apo (ligand free) form of the nuclear receptor (or possibly antagonist bound receptor) ... associates with class II histone deacetylases) LCoR (ligand-dependent corepressor) Nuclear receptor CO-Repressor (NCOR) NCOR1 (NCOR1) NCOR2 (NCOR2)/SMRT (Silencing Mediator (co-repressor) for Retinoid and ...
Jan-Åke Gustafsson - Scientific Discoveries
... group at the Karolinska Institutet discovered estrogen receptor-beta, which plays a pivotal role in the function of the brain, lungs, and immune system ... Today, drugs are being developed to stimulate that receptor to battle a number of diseases, including breast, prostate and lung cancers ... tumors can be slowed down or stopped by stimulating the receptor ...
PPARGC1A
... binding • protein binding • transcription factor binding • ligand-dependent nuclear receptor binding • ligand-dependent nuclear receptor ... This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors ... the activities of, cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs) ...

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