Mukaiyama Aldol

Aldol Reaction - Modern Variations and Methods - Organocatalysis
... It is interesting to note that proline-catalyzed aldol reactions do not show any non-linear effects (the enantioselectivity of the products is directly proportional to the ... studies, the proposed reaction mechanism for proline-catalyzed aldol reactions is as follows This strategy allows the otherwise challenging cross-aldol reaction between two aldehydes ... In general, cross-aldol reactions between aldehydes are typically challenging because they can polymerize easily or react unselectively to give a statistical mixture of products ...

Modern Variations and Methods - Mukaiyama Aldol Reaction
... The Mukaiyama aldol reaction is the nucleophilic addition of silyl enol ethers to aldehydes catalyzed by a Lewis acid such as boron trifluoride or titanium ... The Mukaiyama aldol reaction does not follow the Zimmerman-Traxler model ... The analogous vinylogous Mukaiyama aldol process can also be rendered catalytic and asymmetric ...