Magnetic Tweezers

Magnetic Tweezers

Magnetic tweezers (MT) are scientific instruments for the manipulation and characterization of biomolecules or polymers. These apparatus exert forces and torques to individual molecules or groups of molecules. It can be used to measure the tensile strength or the force generated by molecules.

Most commonly magnetic tweezers are used to study mechanical properties of biological macromolecules like DNA or proteins in single-molecule experiments. Other applications are the rheology of soft matter, and studies of force-regulated processes in living cells. Forces are typically on the order of pico- to nanonewtons. Due to their simple architecture, magnetic tweezers are a popular biophysical tool.

In experiments, the molecule of interest is attached to a magnetic microparticle. The magnetic tweezer is equipped with magnets that are used to manipulate the magnetic particles whose position is measured with the help of video microscopy.

Read more about Magnetic TweezersConstruction Principle and Physics of Magnetic Tweezers, Force Calibration, Comparison To Other Techniques, Typical Experimental Set-up

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Magnetic Tweezers - Typical Experimental Set-up
... Allemand, Croquette with the help of magnetic tweezers ... on one end to a glass surface and on the other to a magnetic micro bead, which can be manipulated in a magnetic tweezers apparatus ... While twisting, the magnetic tweezers also allow stretching the DNA molecule ...

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