Kirke may refer to:
- David Kirke, English adventurer, colonizer and governor
- David Kirke (DSC), English bungee jumper
- Ian Kirke, English rugby league footballer
- Percy Kirke, English soldier
- Simon Kirke, English musician
- Circe or Kírkē, a goddess in Greek mythology
- Kirke University, fictional setting of Campus (TV series)