AIDS ("acquired immune deficiency syndrome") is caused by the human immunodeficiency virus (HIV). Individuals with HIV have what is referred to as a "HIV infection". When infected semen, vaginal secretions, or blood come in contact with the mucous membranes or broken skin of an uninfected person, HIV may be transferred to the uninfected person ("horizontal transfer"), causing another infection. Additionally, HIV can also be passed from infected pregnant women to their uninfected baby during pregnancy and/or delivery ("vertical transmission"), or via breastfeeding. As a result of HIV infection, a portion of these individuals will progress and go on to develop clinically significant AIDS.
HIV is a retrovirus, which comprise a large and diverse family of RNA viruses that make a DNA copy of their RNA genome after infection of a host cell. An essential step in the replication cycle of HIV-1 and other retroviruses is the integration of this viral DNA into the host DNA. The RNA genome of progeny virions and the template for translation of viral proteins are made when the integrated viral DNA is transcribed.
Other articles related to "hiv integration, integration":
... Ciuffi, Angela Bushman, Frederic D Retroviral DNA integration HIV and the role of LEDGF/p75, Trends in Genetics, Volume 22, Issue 7, July 2006, Pages 388-395, ISSN 0168-9 ... Bishop, Correct integration of retroviral DNA in vitro Cell, 49 (1987), pp. 347–356 Bushman, et al.1990, Retroviral DNA integration directed by HIV integration protein in vitro, Science, 28 (1990), pp ...
Famous quotes containing the word integration:
“The more specific idea of evolution now reached isa change from an indefinite, incoherent homogeneity to a definite, coherent heterogeneity, accompanying the dissipation of motion and integration of matter.”
—Herbert Spencer (18201903)