Abnormal Iris Darker
- Deposition of material
- Siderosis – iron deposition within ocular tissues due to a penetrating injury and a retained iron-containing, intraocular foreign body.
- Hemosiderosis – long standing hyphema (blood in the anterior chamber) following blunt trauma to the eye may lead to iron deposition from blood products
- Certain eyedrops – prostaglandin analogues (latanoprost, isopropyl unoprostone, travoprost, and bimatoprost) are used topically to lower intraocular pressure in glaucoma patients. A concentric heterochromia has developed in some patients applying these drugs. The stroma around the iris sphincter muscle becomes darker than the peripheral stroma. A stimulation of melanin synthesis within iris melanocytes has been postulated.
- Neoplasm – Nevi and melanomatous tumors.
- Iridocorneal endothelium syndrome
- Iris ectropion syndrome
Read more about this topic: Heterochromia Iridum, Classification, Acquired Heterochromia
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