Heparin

Heparin (from Ancient Greek ηπαρ (hepar), liver), also known as unfractionated heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines.

Although it is used principally in medicine for anticoagulation, its true physiological role in the body remains unclear, because blood anti-coagulation is achieved mostly by heparan sulfate proteoglycans derived from endothelial cells. Heparin is usually stored within the secretory granules of mast cells and released only into the vasculature at sites of tissue injury. It has been proposed that, rather than anticoagulation, the main purpose of heparin is defense at such sites against invading bacteria and other foreign materials. In addition, it is conserved across a number of widely different species, including some invertebrates that do not have a similar blood coagulation system.

Read more about HeparinHeparin Structure, Medical Use, Natural Degradation or Clearance, De-polymerisation Techniques, Evolutionary Conservation, Other Uses/information, Heparin Impurities and Contamination Recalls, Toxicology, Shelf Life

Other articles related to "heparin":

Scientific Protein Laboratories - History
... The company harvests heparin from pig's intestines in Changzhou City, China and supplies the crude heparin to Baxter Travenol ... The company was involved in the 2008 Chinese heparin adulteration ...
Hypercoagulability In Pregnancy - Prevention of Thrombosis With Anticoagulants - Cautions
... osteoporosis (occurring in up to 1% of cases), thrombocytopenia (heparin-induced thrombocytopenia), haemorrhage, hair loss and drug allergy ... Still, LMWHs are much less likely to cause heparin-induced thrombocytopenia than unfractionated heparin ...
Tinzaparin Sodium
... Tinzaparin is an antithrombotic drug in the heparin group ... It is a low molecular weight heparin (LMWH) marketed as Innohep worldwide ... Tinzaparin sodium is the only low molecular weight heparin shown to be safe in pregnancy and in critically ill people with renal failure at both treatment and prophylaxis ...
Secreted Frizzled-related Protein 1 - As A Drug Target
... Heparin and heparan sulfate (HS) are mammalian glycosaminoglycans with the highest negative charge density of known biological macromolecules ... Heparin is widely used as an injectable anticoagulant ... SFRP1 are heparin-binding proteins, with the heparin-binding domain within the C-terminal region of the SFRP1 protein ...