Heme

A heme (American English) or haem (British English) is a prosthetic group that consists of an iron ion contained in the center of a large heterocyclic organic ring called a porphyrin. Not all porphyrins contain iron, but a substantial fraction of porphyrin-containing metalloproteins have heme as their prosthetic group; these are known as hemoproteins. Hemes are most commonly recognized in their presence as components of hemoglobin, the red pigment in blood, but they are also components of a number of other hemoproteins.

Read more about HemeFunction, Synthesis, Degradation, Heme in Health and Disease, Genes

Other articles related to "heme":

Hemozoin - Formation
... Oxidative stress is believed to be generated during the conversion of heme (ferroprotoporphyrin) to hematin (ferriprotoporphyrin) ... nanometres long and each contain about 80,000 heme molecules ... from the detoxification process in mammals, where an enzyme called heme oxygenase instead breaks excess heme into biliverdin, iron, and carbon monoxide ...
Main Subunit Of Cytochrome C Oxidase
... Proton pumping heme-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes ... The CuB-heme a3 (or heme o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases (EC 1.10.3), is directly involved in the coupling between ... subunit (equivalent to mammalian subunit I (CO I)) is found in all heme-copper respiratory oxidases ...
Soluble Guanylyl Cyclase - Regulation
... bonding prefers a bent geometry for the heme-NO complex ... Thus nitric oxide binding ferrous heme at the distal position gives a His-Fe-NO complex that dissociates to a 5-coordinate Fe-NO complex ... An alternative hypothesis states that a second, non-heme binding site accounts for the second NO dependent activation process to give the fully active ...
Biocrystallization - Heme
... avoid destruction by this molecule, the parasite biocrystallizes heme to form hemozoin ... Heme biocrystallization has been found in blood feeding organisms of great medical importance including Plasmodium, Rhodnius and Schistosoma ... Heme biocrystallization is inhibited by quinoline antimalarials such as Chloroquine ...
Heme - Genes
... The following genes are part of the chemical pathway for making heme ALAD aminolevulinic acid, delta-, dehydratase ALAS1 aminolevulinate, delta-, synthase 1 ALAS2 aminolevulinate, delta ...