Glial Scar

Glial scar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the Central Nervous System. As with scarring in other organs and tissues, the glial scar is the body's mechanism to protect and begin the healing process in the nervous system.

In the context of neurodegeneration, formation of the glial scar has been shown to have both beneficial and detrimental effects. Particularly, many neuro-developmental inhibitor molecules are secreted by the cells within the scar that prevent complete physical and functional recovery of the central nervous system after injury or disease. On the other hand, absence of the glial scar has been associated with impairments in the repair of the blood brain barrier.

Read more about Glial ScarBeneficial Effects of The Scar, Detrimental Effects of The Scar, Primary Scar Molecular Inducers, Suppression of Glial Scar Formation

Other articles related to "scar, glial, glial scar":

Neuroregeneration - Inhibition of Axonal Regrowth - Chondroitin Sulfate Proteoglycan
... In response to scar-inducing factors, like those discussed above, astrocytes up regulate the production of chondroitin sulfate proteoglycans ... Astrocytes are a predominant type of glial cell in the central nervous system that provide many functions including damage mitigation, repair, and glial scar formation ... cortex, as well as those present following injury and the resultant mature glial scar ...
Gliosis - Astrogliosis
... and involves the proliferation of astrocytes, a type of glial cell responsible for maintaining extracellular ion and neurotransmitter concentrations, modulating synapse function ... in their extreme form are most closely associated with the formation of a glial scar, astrogliosis is not an all-or-none process in which a glial scar forms ... minor hypertrophy to major hypertrophy, domain overlap, and ultimately, glial scar formation ...
Suppression of Glial Scar Formation - Recombinant Monoclonal Antibody To Interleukin-6 Receptor
... Interleukin-6 (IL-6) is thought to be a molecular mediator of glial scar formation ... and this decrease was associated with a reduction in glial scarring ...
... Gliosis is a nonspecific reactive change of glial cells in response to damage to the central nervous system (CNS) ... or hypertrophy of several different types of glial cells, including astrocytes, microglia, and oligodendrocytes ... proliferation associated with gliosis leads to the formation of a glial scar ...

Famous quotes containing the word scar:

    Nothing is uglier than the sinner, nothing so leprous or fetid; the scar of his crimes is still raw, and he stinks like the cave of Hell.
    Aurelius Clemens Prudentius (c. 348–405)