Fibromyalgia (FM or FMS) is a medical disorder characterized by chronic widespread pain and allodynia, a heightened and painful response to pressure. Fibromyalgia symptoms are not restricted to pain, leading to the use of the alternative term fibromyalgia syndrome for the condition. Other symptoms include debilitating fatigue, sleep disturbance, and joint stiffness. Some patients also report difficulty with swallowing, bowel and bladder abnormalities, numbness and tingling, and cognitive dysfunction. Fibromyalgia is frequently comorbid with psychiatric conditions such as depression and anxiety and stress-related disorders such as posttraumatic stress disorder. Not all fibromyalgia patients experience all associated symptoms. Fibromyalgia is estimated to affect 2–4% of the population, with a female to male incidence ratio of approximately 9:1. The term "fibromyalgia" derives from new Latin, fibro-, meaning "fibrous tissues", Greek myo-, "muscle", and Greek algos-, "pain"; thus the term literally means "muscle and connective tissue pain".

The brains of fibromyalgia patients show functional and structural differences from those of healthy individuals, but it is unclear whether the brain anomalies cause fibromyalgia symptoms or are the product of an unknown underlying common cause. Some research suggests that these brain anomalies may be the result of childhood stress, or prolonged or severe stress.

Historically, fibromyalgia has been considered either a musculoskeletal disease or neuropsychiatric condition. Although there is as yet no cure for fibromyalgia, some treatments have been shown by controlled clinical trials to effectively reduce symptoms, including medications, behavioral interventions, patient education, and exercise. The most recent approach of a diagnosis of fibromyalgia involves pain index and a measure of key symptoms and severity.

Fibromyalgia has been recognized as a diagnosable disorder by the US National Institutes of Health and the American College of Rheumatology. Fibromyalgia, a central nervous system disorder, is described as a 'central sensitization syndrome' caused by neurobiological abnormalities which act to produce physiological pain and cognitive impairments as well as neuro-psychological symptomatology. Despite this, some health care providers remain skeptical about fibromyalgia as a disease because of a lack of abnormalities on physical examination and the absence of objective diagnostic tests.

Read more about Fibromyalgia:  Signs and Symptoms, Cause, Diagnosis, Treatment, Health Care Utilization, Prognosis, Epidemiology, History, Controversies

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Cyclobenzaprine - Research
... A formulation of cyclobenzaprine is being developed for the management of fibromyalgia by Tonix Pharmaceuticals ... cyclobenzaprine is designed to address the non-restorative sleep feature of fibromyalgia ... given at bedtime was shown to significantly improve core fibromyalgia symptoms and was well tolerated ...
Living With Fibromyalgia - Release
... Hosted by The National Fibromyalgia Association and Trillusion Media, the film had its world première in San Diego on March 22, 2007 at the Hillcrest Landmark Theatre ... the United States as part of the National Fibromyalgia Association’s May, 2007 Fibromyalgia Awareness Day campaign ...
Fibromyalgia - Controversies
... Fibromyalgia continues to be a disputed diagnosis ... Many members of the medical community do not consider fibromyalgia a disease because of a lack of abnormalities on physical examination, and the absence of objective diagnostic tests ... Several theories propose that fibromyalgia is a somatoform disorder ...
Myofascial Pain Syndrome - Symptoms - MPS and Fibromyalgia
... MPS and fibromyalgia share some common symptoms, such as hyperirritability, but the two conditions are distinct ... However, a patient may suffer from MPS and fibromyalgia at the same time ... In fibromyalgia, chronic pain and hyperirritability are pervasive ...
Living With Fibromyalgia
... Living With Fibromyalgia A Journey of Hope and Understanding is a 2007 documentary film by Stephen Eyer and Daneen Akers from Trillusion Media, Inc ... film that explores the chronic pain condition known as fibromyalgia ...