Excision Repair

Excision repair is a term applied to several DNA repair mechanisms. They remove the damaged nucleotides and are able to determine the correct sequence from the complementary strand of DNA.

Specific mechanisms include:

  • Base excision repair (BER), which repairs damage due to a single nucleotide caused by oxidation, alkylation, hydrolysis, or deamination;
  • Nucleotide excision repair (NER), which repairs damage affecting 2−30 nucleotide-length strands. These include bulky, helix distorting damage, such as thymine dimerization and other types of cyclobutyl dimerization caused by UV light as well as single-strand breaks. A specialized form of NER known as Transcription-Coupled Repair (TCR) deploys high-priority NER repair enzymes to genes that are being actively transcribed;
  • Mismatch repair (MMR), which corrects errors of DNA replication and recombination that result in mispaired nucleotides.


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DNA repair
Excision repair
  • Base excision repair/AP site
    • DNA glycosylase
    • Uracil-DNA glycosylase
    • Poly ADP ribose polymerase
  • Nucleotide excision repair/ERCC
    • XPA
    • XPB
    • XPC
    • XPD/ERCC2
    • XPE/DDB1
    • XPF/DDB1
    • XPG/ERCC5
    • ERCC1
    • RPA
    • RAD23A
    • RAD23B
    • Excinuclease
  • DNA mismatch repair
    • MLH1
    • MSH2
Other forms of repair
  • Transcription-coupled repair
    • ERCC6
    • ERCC8
  • Homology directed repair
  • Non-homologous end joining
    • Ku
  • Microhomology-mediated end joining
  • Postreplication repair
  • Photolyase
    • CRY1
    • CRY2
Other/ungrouped proteins
  • Ogt
  • PcrA
  • Proliferating Cell Nuclear Antigen
  • Homologous recombination
    • RecA
    • Sgs1
    • Slx4
Regulation
  • SOS box
  • SOS response
Other/ungrouped
  • 8-Oxoguanine
  • Adaptive response
  • Meiotic recombination checkpoint
  • RecF pathway
  • DNA helicase: BLM
  • WRN
  • FANC proteins: core protein complex
    • FANCA
    • FANCB
    • FANCC
    • FANCE
    • FANCF
    • FANCG
    • FANCL
    • FANCM
  • FANCD1
  • FANCD2
  • FANCI
  • FANCJ
  • FANCN
See also: DNA repair-deficiency disorder B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

Other articles related to "excision repair, excision, repair":

RAD23A
... component • proteasome complex • nucleus Biological process • nucleotide-excision repair • virus-host interaction • regulation of proteasomal ubiquitin-dependent protein catabolic process ... cerevisiae Rad23, a protein involved in nucleotide excision repair (NER) ... protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision ...
Possible Mechanisms of Active DNA Demethylation
... mismatch), followed by insertion of unmethylated one using base excision repair machinery (BER) ... Removal of entire DNA patch and following filling it with new nucleotides by nucleotide excision repair (NER) ... shown to be repaired by TDG, a glycosylase which is involved in base excision repair ...
Homology Directed Repair - Reference and Further Reading
... Regulation of DNA double-strand break repair pathway choice (Full Free PDF Article) DNA repair Excision repair Base excision repair/AP site DNA glycosylase ...
RNA Polymerase II Holoenzyme - Genome Surveillance Complex
... in transcription initiation and DNA repair ... is involved in transcription initiation and DNA repair ... The nucleotide excision repair (NER) pathway is a mechanism to repair damage to DNA ...

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