Deamination

Deamination is the removal of an amine group from a molecule. Enzymes which catalyse this reaction are called deaminases.

In the human body, deamination takes place primarily in the liver, however glutamate is also deaminated in the kidneys. Deamination is the process by which amino acids are broken down if there is an excess of protein intake. The amino group is removed from the amino acid and converted to ammonia. The rest of the amino acid is made up of mostly carbon and hydrogen, and is recycled or oxidized for energy. Ammonia is toxic to the human system, and enzymes convert it to urea or uric acid by addition of carbon dioxide molecules (which is not considered a deamination process) in the urea cycle, which also takes place in the liver. Urea and uric acid can safely diffuse into the blood and then be excreted in urine.

Read more about DeaminationAdditional Proteins Performing This Function

Other articles related to "deamination":

APOBEC3G - Mechanism of Action - Cytidine Deamination and Hypermutation
... AID, it is likely that the mechanism mediated by APOBEC3G for cytidine deamination is similar to that of an E ... The predicted deamination reaction is driven by a direct nucleophilic attack on position 4 of the cytidine pyrimidine ring by the zinc-coordinated enzyme ... The deamination (and resulting oxidation) at position 4 yields a carbonyl group and results in a change from cytidine to uridine ...
Base Excision Repair - Lesions Processed By BER
... damaged by a variety of mechanisms, the most common ones being deamination, oxidation, and alkylation ... FapyA) Alkylated bases 3-methyladenine, 7-methylguanine Deaminated bases hypoxanthine formed from deamination of adenine ... Xanthine formed from deamination of guanine ...
Oxidative Deamination
... Oxidative deamination is a form of deamination that generates oxoacids in the liver. ...
Cytosine - Chemical Reactions
... However, it is inherently unstable, and can change into uracil (spontaneous deamination) ... Active enzymatic deamination of cytosine or 5-methylcytosine by the APOBEC family of cytosine deaminases could have both beneficial and detrimental implications on various ... The implications of deamination on 5-hydroxymethylcytosine, on the other hand, remains less understood ...