CBLC

CBLC

Identifiers Symbols CBLC; CBL-3; CBL-SL; RNF57 External IDs OMIM: 608453 MGI: 1931457 HomoloGene: 8108 GeneCards: CBLC Gene

Gene Ontology
Molecular function phosphotyrosine binding
ubiquitin-protein ligase activity
signal transducer activity
epidermal growth factor receptor binding
calcium ion binding
zinc ion binding
SH3 domain binding
Cellular component nucleus
Biological process cell surface receptor signaling pathway
negative regulation of epidermal growth factor-activated receptor activity
negative regulation of epidermal growth factor receptor signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of MAP kinase activity
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23624 80794 Ensembl ENSG00000142273 ENSMUSG00000040525 UniProt Q9ULV8 Q80XL1 RefSeq (mRNA) NM_001130852 NM_001161844 RefSeq (protein) NP_001124324 NP_001155316 Location (UCSC) Chr 19:
45.28 – 45.3 Mb Chr 7:
19.78 – 19.8 Mb PubMed search

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).

Read more about CBLC:  Interactions

Other articles related to "cblc":

CBLC - Interactions
... CBLC has been shown to interact with FYN and Epidermal growth factor receptor. ...