CBLC
Gene Ontology | |
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Molecular function | • phosphotyrosine binding • ubiquitin-protein ligase activity • signal transducer activity • epidermal growth factor receptor binding • calcium ion binding • zinc ion binding • SH3 domain binding |
Cellular component | • nucleus |
Biological process | • cell surface receptor signaling pathway • negative regulation of epidermal growth factor-activated receptor activity • negative regulation of epidermal growth factor receptor signaling pathway • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of MAP kinase activity |
Sources: Amigo / QuickGO |
45.28 – 45.3 Mb
19.78 – 19.8 Mb
Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.
CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).
Read more about CBLC: Interactions
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