CBLC

CBLC

Identifiers Symbols CBLC; CBL-3; CBL-SL; RNF57 External IDs OMIM: 608453 MGI: 1931457 HomoloGene: 8108 GeneCards: CBLC Gene

Gene Ontology
Molecular function	• phosphotyrosine binding • ubiquitin-protein ligase activity • signal transducer activity • epidermal growth factor receptor binding • calcium ion binding • zinc ion binding • SH3 domain binding
Cellular component	• nucleus
Biological process	• cell surface receptor signaling pathway • negative regulation of epidermal growth factor-activated receptor activity • negative regulation of epidermal growth factor receptor signaling pathway • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of MAP kinase activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23624 80794 Ensembl ENSG00000142273 ENSMUSG00000040525 UniProt Q9ULV8 Q80XL1 RefSeq (mRNA) NM_001130852 NM_001161844 RefSeq (protein) NP_001124324 NP_001155316 Location (UCSC) Chr 19:
45.28 – 45.3 Mb Chr 7:
19.78 – 19.8 Mb PubMed search

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).