Asymmetric Mannich

Asymmetric Mannich Reactions
... Progress has been made towards asymmetric Mannich reactions ... properly functionalized the newly formed ethylene bridge in the Mannich adduct has two prochiral centers giving rise to two diastereomeric pairs of ... The first asymmetric Mannich reaction with an unmodified aldehyde was carried with (S)-proline as a naturally occurring chiral catalyst ...