Activation Segment

Some articles on activation segment, segment, activation:

PIM2 (gene) - Mechanism
... by the presence of the conserved lysine, a closed lobe conformation, and a well-structured activation segment ... The activation segment often necessitates phosphorylation in order for there to be catalytic activity ... Once phosphorylated, the active segment folds onto the lower lobe and reorganizes the peptide-binding site, which consequently leads to enzymatic activation ...
BRAF (gene) - Clinical Significance - BRAF Mutants
... codon 600 (now referred to as V600E) in the activation segment that has been found in human cancers ... to two regions the glycine-rich P loop of the N lobe and the activation segment and flanking regions ... These mutations change the activation segment from inactive state to active state, for example in the previous cited paper it has been reported that the aliphatic ...