SNP Genotyping

SNP genotyping is the measurement of genetic variations of single nucleotide polymorphisms (SNPs) between members of a species. It is a form of genotyping, which is the measurement of more general genetic variation. SNPs are one of the most common types of genetic variation. A SNP is a single base pair mutation at a specific locus, usually consisting of two alleles (where the rare allele frequency is >1%). SNPs are found to be involved in the etiology of many human diseases and are becoming of particular interest in pharmacogenetics. Because SNPs are conserved during evolution, they have been proposed as markers for use in quantitative trait loci (QTL) analysis and in association studies in place of microsatellites. The use of SNPs is being extended in the HapMap project, which aims to provide the minimal set of SNPs needed to genotype the human genome. SNPs can also provide a genetic fingerprint for use in identity testing. The increase in interest in SNPs has been reflected by the furious development of a diverse range of SNP genotyping methods.

Read more about SNP GenotypingHybridization-based Methods, Enzyme-based Methods, Other Post-amplification Methods Based On Physical Properties of DNA, Sequencing

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Personal Genomics - Projects and Services Already Available
... charged $1100 to carry out genotyping of approximately 1 million SNPs and provided risk estimates for 47 diseases as well as ancestry analyses ... Navigenics, began offering SNP-based genomic risk assessments as of April 2008 ... Affymetrix Genome-Wide Human SNP Array 6.0, which genotypes 900,000 SNPs ...
SNP Genotyping - Sequencing
... for sequencing small regions to perform SNP genotyping ... Compared to other SNP genotyping methods, sequencing is in particular, suited to identifying multiple SNPs in a small region, such as the highly polymorphic Major ...