Reverse Genetics

Reverse genetics is an approach to discover the function of a gene by analyzing the phenotypic effects of specific gene sequences obtained by DNA sequencing. This investigative process proceeds in the opposite direction of so-called forward genetic screens of classical genetics. Simply put, while forward genetics seeks to find the genetic basis of a phenotype or trait, reverse genetics seeks to find what phenotypes arise as a result of particular genes.

Automated DNA sequencing generates large volumes of genomic sequence data relatively rapidly. Many genetic sequences are discovered in advance of other, less easily obtained, biological information. Reverse genetics attempts to connect a given genetic sequence with specific effects on the organism.

Read more about Reverse GeneticsTechniques Used in Reverse Genetics

Other articles related to "reverse genetics, genetic, reverse genetic":

Influenza Research - Vaccines - Reverse Genetics
... A technique called reverse genetics allows scientists to manipulate the genomes of influenza viruses and to transfer genes between viral strains ... By removing or modifying certain virulence genes, reverse genetics also can be used to convert highly pathogenic influenza viruses into vaccine candidates that are safer for vaccine ...
Molecular Genetics - Reverse Genetics
... While forward genetic screens are productive, a more straightforward approach is to simply determine the phenotype that results from mutating a given gene ... This is called reverse genetics ... Alternative methods of reverse genetic research include the random induction of DNA deletions and subsequent selection for deletions in a gene of ...
Techniques Used in Reverse Genetics - Interference Using Transgenes
... A molecular genetic approach is the creation of transgenic organisms that overexpress a normal gene of interest ...

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