Dock8 (Dedicator of cytokinesis 8), also known as Zir3, is a large (~190 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins.

Read more about Dock8:  Discovery, Function, Dock8 in Disease

Other articles related to "dock8":

Dock8 in Disease
... little is known about the cellular role of Dock8 its importance has been highlighted in several studies which have identified distruption of the DOCK8 gene in disease ... Deletion and reduced expression of Dock8 have been reported in a human lung cancer cell line and Dock8 was also identified as a putative candidate gene associated with progression of ... Interestingly, Dock8 has been reported to be disrupted in two unrelated patients with mental retardation ...