DNA Polymerase Beta

DNA Polymerase Beta

Identifiers Symbols POLB; MGC125976 External IDs OMIM: 174760 MGI: 97740 HomoloGene: 2013 ChEMBL: 2392 GeneCards: POLB Gene EC number 2.7.7.7

Gene Ontology
Molecular function damaged DNA binding
DNA-directed DNA polymerase activity
protein binding
microtubule binding
lyase activity
enzyme binding
metal ion binding
Cellular component nucleus
nucleoplasm
cytoplasm
microtubule
spindle microtubule
Biological process DNA-dependent DNA replication
DNA repair
base-excision repair
pyrimidine dimer repair
nucleotide-excision repair, DNA gap filling
response to DNA damage stimulus
cell death
response to ethanol
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5423 18970 Ensembl ENSG00000070501 ENSMUSG00000031536 UniProt P06746 Q8K409 RefSeq (mRNA) NM_002690 NM_011130 RefSeq (protein) NP_002681 NP_035260 Location (UCSC) Chr 8:
42.2 – 42.23 Mb Chr 8:
22.63 – 22.65 Mb PubMed search
Stem loopII regulatory element in POLB
Predicted secondary structure of the stem loopII (M2) regulatory element in POLB
Identifiers
Symbol POLB
Rfam RF01455
Entrez 5423
HUGO POLB
OMIM 174760
RefSeq NM_002690
Other data
RNA type Cis-reg
Domain(s) Mammalia
Locus Chr. 8 p11.2

Polymerase (DNA directed), beta, also known as POLB, is an enzyme that, in humans, is encoded by the POLB gene.

Read more about DNA Polymerase Beta:  Function, Regulation of Expression, Interactions

Other articles related to "polymerase, dna polymerase, dna, polymerases, dna polymerase beta":

Polymerase
... A polymerase is an enzyme whose central biological function is the synthesis of polymers of nucleic acids ... DNA polymerase and RNA polymerase are used to assemble DNA and RNA molecules, respectively, generally by copying a DNA or RNA template strand using base-pairing ... generation of other biopolymers are not also referred to as polymerases ...
Streptolydigin
... acid chain elongation by binding to the polymerase, thus stopping RNA polymerase activity inside a cell ... Specifically, it inhibits the assembly of the RNA polymerase II transcription complex and DNA polymerase III transcription ...
DNA Polymerase Beta - Interactions
... DNA polymerase beta has been shown to interact with PNKP and XRCC1. ...
TOPO Cloning - Technique
... The linear vector DNA already has the topoisomerase enzyme covalently attached to both of its strands' free 3' ends ... types of vectors are used for cloning fragments amplified by either Taq or Pfu polymerase as Taq polymerase (unlike Pfu) leaves an extra "A" nucleotide at the 3'end during ... (A) and thymine (T) (complementary basepairs) on different DNA fragments to hybridize and, in the presence of ligase or topoisomerase, become ligated together ...
T7 DNA Polymerase
... The T7 DNA polymerase of the T7 bacteriophage is a DNA-dependent DNA polymerase responsible for the fast rate of T7 phage DNA replication in vivo ... The polymerase consists of a 11 complex of the viral T7 gene 5 protein (80kDA) and the E ... This polymerase is unique due to its considerable processivity, or ability to stay on DNA for a greater than average number of base pairs ...

Famous quotes containing the word dna:

    Here [in London, history] ... seemed the very fabric of things, as if the city were a single growth of stone and brick, uncounted strata of message and meaning, age upon age, generated over the centuries to the dictates of some now all-but-unreadable DNA of commerce and empire.
    William Gibson (b. 1948)