DNA Polymerase Beta

DNA Polymerase Beta

Identifiers Symbols POLB; MGC125976 External IDs OMIM: 174760 MGI: 97740 HomoloGene: 2013 ChEMBL: 2392 GeneCards: POLB Gene EC number 2.7.7.7

Gene Ontology
Molecular function	• damaged DNA binding • DNA-directed DNA polymerase activity • protein binding • microtubule binding • lyase activity • enzyme binding • metal ion binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • microtubule • spindle microtubule
Biological process	• DNA-dependent DNA replication • DNA repair • base-excision repair • pyrimidine dimer repair • nucleotide-excision repair, DNA gap filling • response to DNA damage stimulus • cell death • response to ethanol
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5423 18970 Ensembl ENSG00000070501 ENSMUSG00000031536 UniProt P06746 Q8K409 RefSeq (mRNA) NM_002690 NM_011130 RefSeq (protein) NP_002681 NP_035260 Location (UCSC) Chr 8:
42.2 – 42.23 Mb Chr 8:
22.63 – 22.65 Mb PubMed search

Stem loopII regulatory element in POLB
Predicted secondary structure of the stem loopII (M2) regulatory element in POLB
Identifiers
Symbol	POLB
Rfam	RF01455
Entrez	5423
HUGO	POLB
OMIM	174760
RefSeq	NM_002690
Other data
RNA type	Cis-reg
Domain(s)	Mammalia
Locus	Chr. 8 p11.2

Polymerase (DNA directed), beta, also known as POLB, is an enzyme that, in humans, is encoded by the POLB gene.