Cyclodextrin

Cyclodextrin

Cyclodextrins (sometimes called cycloamyloses) are a family of compounds made up of sugar molecules bound together in a ring (cyclic oligosaccharides).

Cyclodextrins are produced from starch by means of enzymatic conversion. They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental engineering. Hydroxypropyl Beta Cyclodextrin (HPβCD) is the chief active compound found in Procter and Gamble's deodorizing product "Febreze" under the brand name "Clenzaire".

Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). The 5-membered macrocycle is not natural. Recently, the largest well-characterized cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, at least 150-membered cyclic oligosaccharides are also known. Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape:

  • α -cyclodextrin: 6-membered sugar ring molecule
  • β -cyclodextrin: 7-membered sugar ring molecule
  • γ -cyclodextrin: 8-membered sugar ring molecule


Read more about Cyclodextrin:  History of Cyclodextrins, Structure, Synthesis, Uses

Other articles related to "cyclodextrin, cyclodextrins":

Alpha-Cyclodextrin
... Alpha-cyclodextrin is a natural, soluble dietary fiber ... Although many dietary fibers appear to bind fat on a 11 ratio alpha-cyclodextrin is the only one that binds on a 19 (fiberfat) ratio ... same, it would appear to follow that the cyclodextrin is actually forming a layer on the surface of the fat droplets ...
Cyclodextrin - Derivatives - Methyl-beta-cyclodextrin
... Both β-cyclodextrin and Methyl-β-cyclodextrin (MβCD) remove cholesterol from cultured cells ... The methylated form MβCD was found to be more efficient than β-cyclodextrin ... hydrophobic cholesterol molecule is easily lodged inside cyclodextrin rings that are then removed ...
Cyclomaltodextrin Glucanotransferase
... Other names in common use include Bacillus macerans amylase, cyclodextrin glucanotransferase, alpha-cyclodextrin glucanotransferase, alpha-cyclodextrin glycosyltransferase, beta-cyclodextrin glucanotransferase, beta ...
Niemann-Pick Disease, Type C - Treatment - Hydroxypropyl-beta-cyclodextrin (HPbCD)
... In April 2009, Hydroxypropyl-beta-cyclodextrin (HPbCD) was approved under compassionate use by the U.S ... Treatment with cyclodextrin has been shown to delay clinical disease onset, reduced intraneuronal storage and secondary markers of neurodegeneration, and significantly increased lifespan in both ... (This is the second time in the United States that cyclodextrin alone has been administered in an attempt treat a fatal pediatric disease ...
Cyclodextrin Glycosyltransferase
... Cyclodextrin glycosyl transferase (also Cyclodextrin glucosyltransferase or Cyclodextrin glucanotransferase) or CGTase for short (EC 2.4.1.19) is a bacterial enzyme belonging to the same ... important being the synthesis of non-reducing cyclic dextrins known as cyclodextrins starting from starch, amylose, and other polysaccharides ...