Cdks

Some articles on cdks, cdk:

Regulation of Eukaryotic Cell Cycle - Role of Cyclins and CDKs
... of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle ... Many of the genes encoding cyclins and CDKs are conserved among all eukaryotes, but in general more complex organisms have more elaborate cell cycle control systems that incorporate more ... Cyclins form the regulatory subunits and CDKs the catalytic subunits of an activated heterodimer cyclins have no catalytic activity and CDKs are inactive in the absence of a partner cyclin ...
CDC20 - Cdc20 and Cdh1
... After metaphase, however, S/M-Cdks are inactivated by APCCdc20, and Cdh1 can exist in a non-phosphorylated state and bind the APC ... This enables the APC to continue to degrade S/M cyclins (and thus S/M Cdks) until they are needed again in the next S-phase ... rises during G1, activativing G1/S Cdks, which in turn phosphorylate Cdh1 and gradually relieve the inhibition on S/M cyclins ...
CDC20 - Regulation
... bind the APC, specific APC subunits must be phosphorylated by Cdk1 (among other Cdks) ... Therefore, when cdk activity is high in mitosis, and the cell must prepare to enter anaphase and exit mitosis, the APCCdc20 complex is activated ... Once active, APCCdc20 promotes the degradation of Cdks by inactivating S/M cyclins ...
Cyclin-dependent Kinase - Medical Significance
... CDKs are considered a potential target for anti-cancer medication ... cell cycle regulation in cancer cells by interfering with CDK action, the cell will die ... At present, some CDK inhibitors such as Seliciclib are undergoing clinical trials ...
CDC20 - Interactions
... S/M cyclins activate cyclin-dependent kinases (Cdks), which have a vast array of downstream effects that work to guide the cell through mitosis ... These processes are dependent on both the APC and Cdc20 When Cdks phosphorylate the APC, Cdc20 can bind and activate it, allowing both the ...