What is vasopressin?

  • (noun): Hormone secreted by the posterior pituitary gland (trade name Pitressin) and also by nerve endings in the hypothalamus; affects blood pressure by stimulating capillary muscles and reduces urine flow by affecting reabsorption of water by kidney tubules.
    Synonyms: antidiuretic hormone, ADH, Pitressin


Identifiers Symbols AVP; ADH; ARVP; AVP-NPII; AVRP; VP External IDs OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP Gene

Gene Ontology
Molecular function protein kinase activity
signal transducer activity
receptor binding
neuropeptide hormone activity
neurohypophyseal hormone activity
V1A vasopressin receptor binding
V1B vasopressin receptor binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Cellular component extracellular region
extracellular space
secretory granule
Biological process maternal aggressive behavior
positive regulation of systemic arterial blood pressure
generation of precursor metabolites and energy
protein phosphorylation
water transport
signal transduction
elevation of cytosolic calcium ion concentration
cell-cell signaling
negative regulation of female receptivity
grooming behavior
locomotory behavior
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of glutamate secretion
positive regulation of cell growth
positive regulation of cAMP biosynthetic process
positive regulation of prostaglandin biosynthetic process
positive regulation of cellular pH reduction
positive regulation of peptidyl-serine phosphorylation
response to nicotine
social behavior
regulation of renal sodium excretion
hyperosmotic salinity response
maternal behavior
negative regulation of apoptotic process
penile erection
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
sodium-independent organic anion transport
response to ethanol
positive regulation of vasoconstriction
multicellular organismal water homeostasis
negative regulation of transmission of nerve impulse
transmembrane transport
ERK1 and ERK2 cascade
protein kinase C signaling cascade
negative regulation of release of cytochrome c from mitochondria
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 551 11998 Ensembl ENSG00000101200 ENSMUSG00000037727 UniProt P01185 P35455 RefSeq (mRNA) NM_000490.4 NM_009732.1 RefSeq (protein) NP_000481.2 NP_033862.1 Location (UCSC) Chr 20:
3.06 – 3.07 Mb Chr 2:
130.58 – 130.58 Mb PubMed search

Arginine vasopressin (AVP), also known as vasopressin, argipressin or antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals. Vasopressin is responsible for regulating the body's retention of water by acting to increase water absorption in the collecting ducts of the kidney nephron. Vasopressin increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the kidney nephron collecting duct plasma membrane. Vasopressin is a peptide hormone that controls the reabsorption of molecules in the tubules of the kidneys by affecting the tissue's permeability. It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary. Most of it is stored in the posterior pituitary to be released into the bloodstream. However, some AVP may also be released directly into the brain, and accumulating evidence suggests it plays an important role in social behavior, bonding, and maternal responses to stress.

Read more about Vasopressin.

Some articles on vasopressin:

Polycystic Kidney Disease - Research Directions
... Various studies on rodents have shown that a hormone, called vasopressin, increases levels of cAMP in the body ... When mice with PKD were given a chemical that blocks vasopressin, there was an impressive decrease in kidney size and some preservation of kidney function ... consumed excessive amounts of water (which decreases levels of vasopressin), a similar result was seen ...
Vasopressin Receptor Antagonist
... A vasopressin receptor antagonist (VRA) is an agent which interferes with action at the vasopressin receptors ...
Pharmacology - Vasopressin Receptor Inhibition
... A vasopressin receptor antagonist is an agent that interferes with action at the vasopressin receptors ...
Carbetocin - Interactions With Other Drugs and Neurotransmitter Systems
... Due to oxytocin’s close sequence homology with vasopressin, oxytocin analogs often bind with much lower affinity to vasopressin receptors V1, in the uterine lining, and V2 ...
Lixivaptan - Vaptans
... The vasopressin receptor antagonists, dubbed vaptans, target the vasopressin hormonal feedback system ... Vasopressin, also called the anti-diuretic hormone or ADH, is an important part of regulation in the circulatory system and is integral to the balance of water in the ... They work by competing for the active sites on cells meant for vasopressin binding—in this way, the vasopressin is blocked from acting, which earns the title of vasopressing antagonists ...