|Molecular function||• protein kinase activity
• signal transducer activity
• receptor binding
• neuropeptide hormone activity
• neurohypophyseal hormone activity
• V1A vasopressin receptor binding
• V1B vasopressin receptor binding
• cysteine-type endopeptidase inhibitor activity involved in apoptotic process
|Cellular component||• extracellular region
• extracellular space
• secretory granule
|Biological process||• maternal aggressive behavior
• positive regulation of systemic arterial blood pressure
• generation of precursor metabolites and energy
• protein phosphorylation
• water transport
• signal transduction
• elevation of cytosolic calcium ion concentration
• cell-cell signaling
• negative regulation of female receptivity
• grooming behavior
• locomotory behavior
• positive regulation of cell proliferation
• positive regulation of gene expression
• positive regulation of glutamate secretion
• positive regulation of cell growth
• positive regulation of cAMP biosynthetic process
• positive regulation of prostaglandin biosynthetic process
• positive regulation of cellular pH reduction
• positive regulation of peptidyl-serine phosphorylation
• response to nicotine
• social behavior
• regulation of renal sodium excretion
• hyperosmotic salinity response
• maternal behavior
• negative regulation of apoptotic process
• penile erection
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
• sodium-independent organic anion transport
• response to ethanol
• positive regulation of vasoconstriction
• multicellular organismal water homeostasis
• negative regulation of transmission of nerve impulse
• transmembrane transport
• ERK1 and ERK2 cascade
• protein kinase C signaling cascade
• negative regulation of release of cytochrome c from mitochondria
|Sources: Amigo / QuickGO|
3.06 – 3.07 Mb
130.58 – 130.58 Mb
Arginine vasopressin (AVP), also known as vasopressin, argipressin or antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals. Vasopressin is responsible for regulating the body's retention of water by acting to increase water absorption in the collecting ducts of the kidney nephron. Vasopressin increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the kidney nephron collecting duct plasma membrane. Vasopressin is a peptide hormone that controls the reabsorption of molecules in the tubules of the kidneys by affecting the tissue's permeability. It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary. Most of it is stored in the posterior pituitary to be released into the bloodstream. However, some AVP may also be released directly into the brain, and accumulating evidence suggests it plays an important role in social behavior, bonding, and maternal responses to stress.
Read more about Vasopressin.
Some articles on vasopressin:
... Various studies on rodents have shown that a hormone, called vasopressin, increases levels of cAMP in the body ... When mice with PKD were given a chemical that blocks vasopressin, there was an impressive decrease in kidney size and some preservation of kidney function ... consumed excessive amounts of water (which decreases levels of vasopressin), a similar result was seen ...
... A vasopressin receptor antagonist (VRA) is an agent which interferes with action at the vasopressin receptors ...
... A vasopressin receptor antagonist is an agent that interferes with action at the vasopressin receptors ...
... Due to oxytocin’s close sequence homology with vasopressin, oxytocin analogs often bind with much lower affinity to vasopressin receptors V1, in the uterine lining, and V2 ...
... The vasopressin receptor antagonists, dubbed vaptans, target the vasopressin hormonal feedback system ... Vasopressin, also called the anti-diuretic hormone or ADH, is an important part of regulation in the circulatory system and is integral to the balance of water in the ... They work by competing for the active sites on cells meant for vasopressin binding—in this way, the vasopressin is blocked from acting, which earns the title of vasopressing antagonists ...