What is senescence?

  • (noun): The property characteristic of old age.
    Synonyms: agedness
    See also — Additional definitions below


Senescence (from Latin: senescere, meaning “to grow old,” from senex) or biological aging is the endogenous and hereditary process of accumulative changes to molecular and cellular structure disrupting metabolism with the passage of time, resulting in deterioration and death. Senescence occurs both on the level of the whole organism (organismal senescence) as well as on the level of its individual cells (cellular senescence). The science of biological aging is biogerontology. Albeit indirectly, senescence is by far the leading cause of death. Of the roughly 150,000 people who die each day across the globe, about two thirds—100,000 per day—die of age-related causes; in industrialized nations, moreover, the proportion is much higher, reaching 90%. Senescence is not the inevitable fate of all organisms, and animal organisms of some groups (taxa) even experience chronological decrease in mortality, for all or part of their life cycle. On the other extreme are accelerated aging diseases, rare in humans. There are a number of hypotheses as to why senescence occurs; for example, some posit it is programmed by gene expression changes, others that it is the cumulative damage caused by biological processes. Whether senescence as a biological process itself can be slowed down, halted or even reversed, is a subject of current scientific speculation and research.

Read more about Senescence.

Some articles on senescence:

Senescence - Miscellaneous
... Recently, a kind of early senescence has been alleged to be a possible unintended outcome of early cloning experiments ... The claim that Dolly's early death involved premature senescence has been vigorously contested, and Dolly's creator, Dr ...
Antagonistic Pleiotropy Hypothesis - Adaptivity and Senescence
... pleiotropy being an explanation for senescence ... Senescence is the act of ageing in individuals it's the failure over time of the individual's life processes by natural causes ... The competing model to explain senescence is Medawar's "mutation accumulation" hypothesis, saying that "over evolutionary time, late-acting mutations will accumulate at a ...
List Of Pear Diseases - Miscellaneous Diseases and Disorders
... deficiency Brown core High CO2 Core breakdown (Bartlett) Senescence Core spot Associated with calcium deficiency Green stain Unknown Internal bark necrosis Unknown Mealy core (d`Anjo ...
Interleukin 8 Receptor, Beta - Senescence
... the chemokine receptor CXCR2 alleviates both replicative and oncogene-induced senescence (OIS) and diminishes the DNA-damage response ... Also, ectopic expression of CXCR2 results in premature senescence via a p53-dependent mechanism ...
Aging (disambiguation) - Senescence
... Senescence, the biological effect of time on an organism Aging in dogs Aging in humans. ...

More definitions of "senescence":

  • (noun): The organic process of growing older and showing the effects of increasing age.
    Synonyms: aging, ageing