What is reverse transcriptase?

  • (noun): A polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses.

Reverse Transcriptase

Reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. RT is needed for the replication of retroviruses (e.g. HIV), and RT inhibitors are widely used as antiretroviral drugs. RT activity is also associated with the replication of chromosome ends (telomerase) and some mobile genetic elements (retrotransposons).

Read more about Reverse Transcriptase.

Some articles on reverse transcriptase:

Retron Msr RNA
... Synthesis of DNA by a retron-encoded reverse transcriptase (RT) results in a DNA-RNA chimera which is composed of small single-stranded DNA linked to small single-stranded RNA ... while the product of the ret gene is a reverse transcriptase similar to the RTs produced by retroviruses and other types of retroelements ... Like other reverse transcriptases, the retron RT contains seven regions of conserved amino acids (labeled 1-7 in the figure), including a highly conserved tyr-ala-asp-asp (YADD) sequence associated with the ...
Dulbecco - Scientific Career - Nobel Prize
... of viral genes to the cell is mediated by an enzyme called reverse transcriptase (or, more precisely, RNA-dependent DNA polymerase), which replicates the ... In addition, it is well-known that in the 1980s and 1990s, an understanding of reverse transcriptase and of the origins, nature, and properties of human immunodeficiency virus (HIV ...
Ann Kiessling - Career
... Kiessling is noted for her discovery of reverse transcriptase activity in normal human cells (Kiessling Goulian) ... to this discovery, it had been assumed that reverse transcriptase was an enzyme found only in retroviruses(such as HIV) ... understand the normal biologic role of reverse transcriptase, Kiessling began to study eggs and early cleaving embryos ...
Reverse Transcriptase - Applications - Molecular Biology
... For more details on this topic, see Reverse transcription polymerase chain reaction ... Reverse transcriptase is commonly used in research to apply the polymerase chain reaction technique to RNA in a technique called reverse transcription polymerase chain reaction (RT-PCR) ... be applied only to DNA strands, but, with the help of reverse transcriptase, RNA can be transcribed into DNA, thus making PCR analysis of RNA molecules possible ...

Famous quotes containing the word reverse:

    They shall beat their swords into plowshares, and their spears into pruninghooks: nation shall not lift up sword against nation, neither shall they learn war any more.
    Bible: Hebrew Isaiah, 2:4.

    The words reappear in Micah 4:3, and the reverse injunction is made in Joel 3:10 (”Beat your plowshares into swords ...”)