What is mast cell?

  • (noun): A large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation.
    Synonyms: mastocyte, labrocyte

Mast Cell

A mast cell (also known as mastocyte and labrocyte) is a resident cell of several types of tissues and contains many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens.

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Some articles on mast cell:

CD117
... protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • stem cell factor receptor activity • protein binding • ATP binding • cytokine binding • protein ...
Mast Cell - Histological Staining
... and glycoaminoglycans, components of mast cells granules ... Surface markers - Cell surface markers of mast cells were referred in detail by Heneberg, claiming that mast cells may be inadverently included in the ... The classical mast cell markers include the high affinity IgE receptor, CD25 (non-neoplastic mast cells), CD117 (c-Kit), CD23 and CD203c (for most of ...
Mast Cell Stabilizer
... Mast cell stabilizers are cromone medications used to prevent or control certain allergic disorders ... They block a calcium channel essential for mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators ... Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate ...
Mast Cell Leukemia - Therapy
... Immunoglobulin E (IgE) is important in mast cell function ... resulted in a transient decrease in the numbers of circulating mast cells in one patient with mast cell leukemia ... Although splenectomy has led to brief responses in patients with mast cell leukemia no firm conclusions as to the efficacy of this treatment are possible ...
Santa J. Ono - Scientific Career
... or de novo on the insulin-producing beta cells of the islets of Langerhans ... to be relevant to the developmental control of B cell differentiation ... determined the role of beta-chemokines in mast cell-dependent inflammation in the ocular surface ...

Famous quotes containing the words cell and/or mast:

    In America all too few blows are struck into flesh. We kill the spirit here, we are experts at that. We use psychic bullets and kill each other cell by cell.
    Norman Mailer (b. 1923)

    What do we plant when we plant the tree?
    We plant the ship that will cross the sea,
    We plant the mast to carry the sails,
    We plant the planks to withstand the gales—
    The keel, the keelson, and beam and knee—
    We plant the ship when we plant the tree.
    Henry Abbey (1842–1911)