What is caspase?

  • (noun): Any of a group of proteases that mediate apoptosis.

Caspase

Caspases, or cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases are a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation.

Read more about Caspase.

Some articles on caspase:

Caspase 6
... NP_033941 Location (UCSC) Chr 4 110.61 – 110.62 Mb Chr 3 129.9 – 129.91 Mb PubMed search Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene ... a protein that is a member of the cysteine-aspartic acid protease (caspase) family ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis ...
Caspase 7
... NP_031637 Location (UCSC) Chr 10 115.44 – 115.49 Mb Chr 19 56.4 – 56.44 Mb PubMed search Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded ... Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis ...
AIM2 - Function
... ASC (or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain) ... ASC also contains a CARD domain (caspase activation and recruitment domain), that recruits procaspase-1 to the complex ... This leads to the autoactivation of caspase-1, an enzyme that processes proinflammatory cytokines (IL-1b and IL-18) ...
Caspase 14
... Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene ... encodes a member of the cysteine-aspartic acid protease (caspase) family ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis ...
Discovery of Caspases, Functions
... Robert Horvitz initially established the importance of caspases in apoptosis and found that the ced-3 gene is required for the cell death that took place during the development of ... converting enzyme (ICE) (now known as caspase 1), which at the time was the only known caspase ... Other mammalian caspases were subsequently identified, in addition to caspases in organisms such as fruit fly Drosophila melanogaster ...