What is alcohol dehydrogenase?

Alcohol Dehydrogenase

Alcohol dehydrogenases (ADH) (EC 1.1.1.1) are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+ to NADH). In humans and many other animals, they serve to break down alcohols that otherwise are toxic, and they also participate in generation of useful aldehyde, ketone, or alcohol groups during biosynthesis of various metabolites. In yeast, plants, and many bacteria, some alcohol dehydrogenases catalyze the opposite reaction as part of fermentation to ensure a constant supply of NAD+.

Read more about Alcohol Dehydrogenase.

Some articles on alcohol dehydrogenase:

Ethylene Glycol Poisoning - Treatment - Antidotes
... Ethanol acts by competing with ethylene glycol for alcohol dehydrogenase, the first enzyme in the degradation pathway ... Because ethanol has a much higher affinity for alcohol dehydrogenase, about a 100-times greater affinity, it successfully blocks the breakdown of ethylene glycol into glycoaldehyde, which prevents the ... Fomepizole is a potent inhibitor of alcohol dehydrogenase similar to ethanol, it acts to block the formation of the toxic metabolites ...
ADH6
... Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene ... This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family ... including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products ...
Adh7
... number 1.1.1.1 Gene Ontology Molecular function • alcohol dehydrogenase (NAD) activity • alcohol dehydrogenase activity, zinc-dependent • aldehyde ... This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family ... including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products ...
Alcool - Toxicity
... All primary alcohols are broken down into aldehydes then to carboxylic acids, and whose toxicities are similar to acetaldehyde and acetic acid ... Some secondary and tertiary alcohols are less poisonous than ethanol because the liver is unable to metabolise them into these toxic by-products ... Ethchlorvynol is a good example of a tertiary alcohol which saw both medicinal and recreational use ...

Famous quotes containing the word alcohol:

    No power on earth or above the bottomless pit has such influence to terrorize and make cowards of men as the liquor power. Satan could not have fallen on a more potent instrument with which to thrall the world. Alcohol is king!
    Eliza “Mother” Stewart (1816–c. 1908)