WARS (gene)

Identifiers Symbols WARS; GAMMA-2; IFI53; IFP53 External IDs OMIM: 191050 MGI: 104630 HomoloGene: 3084 GeneCards: WARS Gene EC number 6.1.1.2

Gene Ontology
Molecular function tryptophan-tRNA ligase activity
protein binding
ATP binding
Cellular component cytoplasm
cytosol
Biological process angiogenesis
translation
tRNA aminoacylation for protein translation
tryptophanyl-tRNA aminoacylation
negative regulation of cell proliferation
gene expression
regulation of angiogenesis
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7453 22375 Ensembl ENSG00000140105 ENSMUSG00000021266 UniProt P23381 P32921 RefSeq (mRNA) NM_004184 NM_001164314 RefSeq (protein) NP_004175 NP_001157786 Location (UCSC) Chr 14:
100.8 – 100.84 Mb Chr 12:
108.86 – 108.89 Mb PubMed search

Tryptophanyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the WARS gene.

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.

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