Vaccinia

Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, and which encodes for approximately 250 genes. The dimensions of the virion are roughly 360 × 270 × 250 nm, with a mass of approximately 5-10 fg. Vaccinia virus is well known for its role as a vaccine (its namesake) that eradicated the smallpox disease, making it the first human disease to be successfully eradicated by science. This endeavour was carried out by the World Health Organization under the Smallpox Eradication Program. Post eradication of smallpox, scientists study Vaccinia virus to use as a tool for delivering genes into biological tissues (gene therapy and genetic engineering).

In the early 21st century, due to concerns about smallpox being used as an agent for bioterrorism, there was renewed interest in studying the Vaccinia virus.

Read more about VacciniaClassification, Origin, Basic Biology, Host Resistance, Use As A Vaccine, History, Recent Cases, Common Strains

Other articles related to "vaccinia":

Vaccinia - Common Strains
... This is a list of some of the well-characterized vaccinia strains used in research and immunizations ... Modified vaccinia Ankara a highly attenuated (not virulent) strain created by passaging vaccinia virus several hundred times in chicken embryo fibroblasts ... Unlike some other vaccinia strains it does not make immunodeficient mice sick and therefore may be safer to use in humans who have weaker immune systems ...
Poxviruses - Taxonomy - Examples - Vaccinia Virus
... The prototypial poxvirus is vaccinia virus, known for its role as the active agent in the eradication of smallpox ... The vaccinia virus is an effective tool for foreign protein expression, as it elicits a strong host immune-response ... The vaccinia virus enters cells primarily by cell fusion, although currently the receptor responsible is unknown ...
Modified Vaccinia Ankara
... Vaccinia viruses re-engineered to express foreign genes are robust vectors for production of recombinant proteins, the most common being a vaccine delivery system for antigens ... Concerns about the safety of the vaccinia virus have been addressed by the development of vectors based on attenuated vaccinia viruses ... One of them, the Modified Vaccinia Ankara (MVA) virus, is a highly attenuated strain of vaccinia virus that was developed towards the end of the campaign for the eradication of smallpox by Professor Anton ...
Rabbitpox - Infection
... may be isolated or the infection diagnosed serologically by methods appropriate to vaccinia ... virus is closely related immunologically to vaccinia virus, consequently rabbits that have been inoculated with the smallpox (vaccinia virus) vaccine have immunity against ...
Smallpox - Cause
... Subfamily Chordopoxvirinae Genus Orthopoxvirus Type species Vaccinia virus Species Variola virus Smallpox is caused by infection with variola virus, which belongs to the genus Orthopoxvirus, the family ... Four orthopoxviruses cause infection in humans variola, vaccinia, cowpox, and monkeypox ... Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature ...